If using a 64 bit Operating System, follow the steps below (SEP 11.x):

1. Open the Registry Editor on the machine where the SEPM is installed.
2. Go to HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Symantec\InstalledApps
   
   
   
3. On the right-hand side, look for the following String entries: SymcData-sesmVirDef32, SymcData-sesmIPSdef32, SymcData-sesmIPSdef64 and SymcData-sesmVirDef64
4. For the following entries, check the value data and confirm that they read as follows:
   
   
   • (Windows 2003) For SymcData-sesmVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmvirdef32
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmipsdef32
      
   • (Windows 2003) For SymcData-sesmVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmvirdef64
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmipsdef64
      
   • (Windows 2008) For SymcData-sesmVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Data\Symantec\Definitions\SymcData\sesmvirdef32
     C:\Program Data\Symantec\Definitions\SymcData\sesmipsdef32
      
   • (Windows 2008) For SymcData-sesmVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Data\Symantec\Definitions\SymcData\sesmvirdef64
     C:\Program Data\Symantec\Definitions\SymcData\sesmipsdef64
      
5. If the value data for these String entries does not match what is described above, modify the String and adjust accordingly
6. Restart SEPM service.
7. Start > Run > LUALL
   
   LiveUpdate will download 32-bit definitions correctly.

If using 32 bit Operating System, follow the steps below (SEP 11.x):

1. On the machine that has the SEPM installed, open the Registry Editor
2. Go to HKEY_LOCAL_MACHINE\SOFTWARE\symantec\InstalledApps
   
   
   
3. On the right-hand side, look for the following String entries: SymcData-sesmvirdef32, SymcData-sesmipsdef32, SymcData-sesmipsdef64 and SymcData-sesmvirdef64
4. For the following entries, check the value data and confirm that they read as follows:
   
   
   • (Windows 2003) For SymcData-sesmVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmvirdef32
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmipsdef32
      
   • (Windows 2003) For SymcData-sesmVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmvirdef64
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmipsdef64
      
   • (Windows 2008) For SymcData-sesmVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\ProgramData\Symantec\Definitions\SymcData\sesmvirdef32
     C:\ProgramData\Symantec\Definitions\SymcData\sesmipsdef32
      
   • (Windows 2008) For SymcData-sesmVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\ProgramData\Symantec\Definitions\SymcData\sesmvirdef64
     C:\ProgramData\Symantec\Definitions\SymcData\sesmipsdef64
     
5. If the value data for these String entries does not match what is described above, modify the String and adjust accordingly
6. Restart SEPM service.
7. Start > Run > LUALL
   
   LiveUpdate will download 32-bit definitions correctly.

If using a 64 bit Operating System, follow the steps below (SEP 12.1.x):

1. Open the Registry Editor on the machine where the SEPM is installed.
2. Go to HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Symantec\InstalledApps
   
3. On the right-hand side, look for the following String entries: SymcData-spcVirDef32, SymcData-spcIPSdef32, SymcData-sesmIPSdef64 and SymcData-spcVirDef64
4. For the following entries, check the value data and confirm that they read as follows:
   
   
   • (Windows 2003) For SymcData-spcVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\spcVirDef32
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmIPSdef32
      
   • (Windows 2003) For SymcData-sesmVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\spcVirDef64
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmIPSdef64
      
   • (Windows 2008) For SymcData-sesmVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Data\Symantec\Definitions\SymcData\spcVirDef32
     C:\Program Data\Symantec\Definitions\SymcData\sesmIPSdef32
      
   • (Windows 2008) For SymcData-sesmVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Data\Symantec\Definitions\SymcData\spcVirDef64
     C:\Program Data\Symantec\Definitions\SymcData\sesmIPSdef64
      
5. If the value data for these String entries does not match what is described above, modify the String and adjust accordingly
6. Restart SEPM service.
7. Start > Run > LUALL
   
   LiveUpdate will download 32-bit definitions correctly.

If using 32 bit Operating System, follow the steps below (SEP 12.1.x):

1. On the machine that has the SEPM installed, open the Registry Editor
2. Go to HKEY_LOCAL_MACHINE\SOFTWARE\symantec\InstalledApps
   
3. On the right-hand side, look for the following String entries: SymcData-spcVirDef32, SymcData-sesmIPSdef32, SymcData-sesmIPSdef64 and SymcData-spcVirDef64
4. For the following entries, check the value data and confirm that they read as follows:
   
   
   • (Windows 2003) For SymcData-spcVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\spcVirDef32
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmIPSdef32
      
   • (Windows 2003) For SymcData-spcVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Files\Common Files\Symantec Shared\SymcData\spcVirDef64
     C:\Program Files\Common Files\Symantec Shared\SymcData\sesmIPSdef64
      
   • (Windows 2008) For SymcData-spcVirDef32 and SymcData-sesmIPSdef32, they always should look as below:
     
     C:\Program Data\Symantec\Definitions\SymcData\spcVirDef32
     C:\Program Files\Symantec\Definitions\SymcData\sesmIPSdef32
      
   • (Windows 2008) For SymcData-spcVirDef64 and SymcData-sesmIPSdef64, they always should look as below:
     
     C:\Program Data\Symantec\Definitions\SymcData\spcVirDef64
     C:\Program Data\Symantec\Definitions\SymcData\sesmIPSdef64
     
5. If the value data for these String entries does not match what is described above, modify the String and adjust accordingly
6. Restart SEPM service.
7. Start > Run > LUALL
   
   LiveUpdate will download 32-bit definitions correctly.

If the above steps do not resolve the issue, uninstall and re-install Symantec Endpoint Protection Manager.

The following articles will help should this be necessary:

About uninstalling Symantec Endpoint Protection Manager
Best Practices for Disaster Recovery with the Symantec Endpoint Protection Manager