There is a KB article available for "Common problems for very large environments" and is #26878. Particularly interesting is the last item under NS relating to IIS and .NET's debug mode for asp pages.
Quite a few solutions that are out right now that mistakenly have Debug enabled. This causes additional load on IIS / NS server.
Turning the debugging off on the asp.net pages should help in these three areas according to the KB article.
Please see KB #33499 for more information and also to get the executable that will turn off debug mode on the .NET pages.
I also found that when I implemented it, it "hung" all Web pages for 2-3 minutes. Probably, while they recompiles. I'd recommend do this during off-peak hours. I did get great performance gains though.