I helped an admin out yesterday who was running out of disk space on a system. It turns out a very large email folder in Thunderbird was triggering a virus alert and an attempt to clean it up, but the cleaning failed. As such, the file was left in quarantine and left on the file system. Each time a scan ran, this happened again and the hard drive slowly filled up. By default, SEP clears items out of quarantine that are over 30 days old. I suggest adding the second option to your systems that also sets a file-size limit. Probably aim high, like 5120 MB or so, since it isn't permanent. This should be enough to prevent systems that had ample hard disk space from running out for some reason caused by SEP and misbehaving software, yet still allow for file recovery in most circumstances.