I have several virtual machines that have been cloned from a vmware image that had Windows 7 and SEP 11 installed. They had been running fine for months with SEP 11, then the 12.1 version came out, so I installed that and they began rebooting shortly after logon (30 seconds). Then I uninstalled SEP 12.1 and put 11 back on after I saw there was a known issue with tamper protection causing reboots and was told to wait until RU1 to fix it.
Today, I installed 12.1 RU1 onto some of those same machines again and had the same problem of rebooting shortly after logon. Also, I want to mention that they are hard reboots as if I reset the virtual machine.
The only "fix" I have seen for this problem is disabling tamper protection when cloning the machine. Obviously I cannot do this because they have been in production and working fine with SEP 11 for at least a few months now.
EDIT: I haven't tried upgrading any of my cloned 2008 servers because it has been so unreliable on Win7, so I can't comment on that aspect