Sierra is not supported on 12.1.6 MP5. It should be supported in the next release 12.1.6 MP6. There is small section on 12.1.6 MP6 here:
http://www.symantec.com/docs/TECH231877
...so the MP6 release must be quite close. Per this link it's "September 2016" but no exact date:
http://www.symantec.com/docs/TECH154475
I haven't seen documented issues yet with Sierra so it could be ok or it may not.