Read : To use the .JDB file to update definitions for Symantec Endpoint Protection Manager: 
http://service1.symantec.com/SUPPORT/ent-security.nsf/docid/2007100820002048

like i said, i did this and only the 32bit servers updated NOT my 64bit.

Check out....

https://www-secure.symantec.com/connect/forums/sep-64-bit-client-not-receiving-definition-updates

A few of us with similar issue.

Paul

Folow this

1. Stop   the SEPM server service.
2. Go to "…\Inetpub\content\{C60DC234-65F9-4674-94AE-62158EFCA433}" folder and deleted all the sub folders
3)  Go to C:\Program Files\Common Files\Symantec Shared\SymcData\ and delete the following folders:
sesmipsdef32
sesmipsdef64
sesmvirdef32
sesmvirdef64
4)In the registry, navigate to HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\InstalledApps.
Delete these keys
SymcData-sesmipsdef32
SymcData-sesmipsdef64
SymcData-sesmvirdef32
SymcData-sesmvirdef64
5). In the registry, navigate to and delete the following keys:
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmipsdef32
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmipsdef64
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmvirdef32
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\SharedDefs\SymcData-sesmvirdef64
6). Start the SEPM service back up.
7) Put the jdb

Symantec Endpoint Protection Manager 11.x is not updating 32 or 64 bit virus definitions. http://service1.symantec.com/support/ent-security....

Tried that - no effect. The keys weren't even recreated. I've uninstalled SEPM and reinstalled and still it won't update 64 bit defs in the manager.

same for me, the 64bit folders arent even there to begin with.

Trying Creating the folders manually and see if that helps

that did not help

I just want to make sure that you are downloading two .jdb files, one for 32 bit and one for 64 bit right? I know this sounds like a stupid question but I had to ask...

Thanks,
Grant-

they are the same exact files, in my opinion thats the problem. the checksum is the same on both files.

I've never had to download two .jdb files before.  I always downloaded the one and both 32bit and 64bit would be updated.

I noticed weeks ago (while my definitions were still updating) that the two jdb files listed were pointing to the same location. Only ever downloaded one file and it always updated both 32 bit and 64 bit definitions. I think the fact there is only one file is not the cause of the problem.

My last 64 bit definitions updated on 4th March with a file containing definitions of 3rd March. I update the server weekly with jdb file as there is no internet connection on any of the machines.

I've cleared out the definitions with the process above, repaired SEPM, upgraded to RU5 from 4r1, uninstalled and reinstalled the manager deleting the database and reconnected all clients, still I get no 64 bit definitions in the manager when loading a jdb file.