Hi,
It depends on the company policy at what frequency it needs to be scanned.
I strongly feel that daily full scan at mid night or lunch hr is compulsory.
Because File System Auto-Protect will scan only the files which are accessed or modfied. But what about the files that are kept in the HDD.
In todays world hard disk capacity are increasing day by day to due the huge demand of data storage in local drives.
One typical example is: If a pen drive of 4 GB or 8 GB is infected by some virus like Sily FDC or Hara kit.
The virus remains with in the drive untill and unless it is fully scanned and the chances of spreading the virus becomes more thru pen drive.