After upgrading 2 clients to SEP 12.1 one of them is experiencing an issue with a custom application that sends email on her behalf.  When this action is attempted she receives a Microsoft Office Outlook popup that states, "A program is trying to access data from Outlook that may include address book information.  Do you want to allow this?"  She has two options Allow or Deny.

In researching why this message is now appearing I have found that its because Windows isnt detecting any valid Antivirus products on the computer.  To verify I opened Outlook 2007 > Tools > Trust Center > Programmatic Access.  At the bottom of this setting it shows if your AV is valid.  This one computer shows, "Antivirus status: Invalid. This version of Windows supports antivirus detection, but no antivirus was found"

This issue did not occur when SEP 11 RU6 was installed.  Now that this client runs SEP 12.1 the problem exists.  Opening the SEP client on this computer I can see it updating and running its morning scans as our policy indicates. So it appears to be working.

The other computer that was upgrade to SEP 12.1 has no problems, and the Antivirus status shows Valid.

I ran diagnostics in Outlook 2007 (Help > Office Diagnostics) and no problems were found.

I am going to remove SEP 12.1 and then re-push it back out from the Console, but I am curious if anybody else is experiencing this issue.

Joshua