First thing is that you build rules the same way whether they are applicability or detection rules.
Using the AND/OR logic you can make rules quite complex but you can only invoke one rule for any Software Release/Update/Service Pack.
If you were really lucky your Applicability Rule might just be:
AND
NOT
Registry Key Exists
HKLM\Software\Adobe\Acrobat
Just make sure you testy your rule on different versions of Adobe Acrobat, you can use a dummy install command line to test.