Thank you for the replies guys.
JL-S: Basically we have 1 management server for about 4500 clients and it is using A LOT of bandwidth out of head office and we find definition updates are going out too slowly. In order to resolve this we have setup two new management servers are replica servers on off-site locations for our second and third largest domains.
We simply want all DOMAIN1 computers to get definitions from NEWSEPSRV1 and all DOMAIN2 computers to get definitions from NEWSEPSRV2, and have all other clients belonging to all other domains to just keep doing what they're doing...getting defs from the main management server.
Kavin mentioned that we can setup conditions so that clients in X domain or subnet get automatically put in X group, and then I assume we can setup a policy for X group to get definition updates from the local server, correct?
Is there a better way we should be going about doing this? The long and short of it is, we want to take 2 domains and give them their own SEP management server to distribute definitions to its local domain, without administrative effort (without us having to constantly sort out clients).