Centralized Exceptions Policies contain exceptions for the following types of scans:
AntiVirus and antispyware scans
TruScan proactive threat scans
Tamper Protection scans
Follow the instructions below for the type of exception you would like to make.
Note: Security Risk Exceptions are global, and apply to all Scheduled Scans as well as Realtime AutoProtect.
Log into the SEPM and click Policies.
Under View Policies click Centralized Exceptions.
Under Tasks click Add a Centralized Exception policy... This will create and open a new Centralized Exceptions Policy.
In the left pane, click Centralized Exceptions.
Click the Add button to open a drop-down menu. Move the cursor over Security Risk Exceptions to open a second drop-down menu.
Select one of the four options: Known Risks, File, Folder, Extensions.
Note: Wildcard variables such as * and ? are not supported.
Note: For File and Folder-based exclusions, the Full Path to the file must be specified, unless a "Prefix Variable" is selected. If a "Prefix Variable" is selected, the path specified should be relative to the selected "Prefix Variable"
Note: if you are unsure about what type of exception to make please see the chapter entitled "Configuring Centralized Exceptions Policies" in the "Administration Guide for Symantec™ Endpoint Protection and Symantec Network Access Control".
Enter the appropriate information for the known risk, file, folder, or extension you would like to exclude.
(Optional) Repeat steps 5 through 7 to add any other Security Risk Exceptions you would like to the policy.
(Optional) Follow the appropriate steps under "Creating exceptions for TruScan proactive threat scans" or "Creating exceptions for Tamper Protection scans" to add those types of exceptions to this policy.
Click OK.
Creating Centralized Exception policies in Symantec Endpoint Protection Manager.
http://service1.symantec.com/SUPPORT/ent-security.nsf/docid/2008030423280248