Hi v_ani,
Thanks for the query. Those .jdb work with any version of SEP 12.1, RU3 and later. Here's an article on the subject:
How to update content on a Symantec Endpoint Protection Manager that does not have Internet access
http://www.symantec.com/docs/TECH104893
...
An alternative option for updating Antivirus and Antispyware definitions is explained in How to update definitions for Symantec Endpoint Protection Manager using the .jdb file. For releases prior to SEP 12.1 RU3, there is no way to update the Proactive Threat Protection (PTP) and Network Threat Protection (NTP) definitions on the SEPM without using LiveUpdate Administrator 2.x. SEPMs running SEP 12.1 RU3 and above can and should update their SONAR ("Behavior-Based Protection") and IPS ("Network-Based Protection") definitions using new .jdb files available from Security Response's Virus Definitions & Security Updates page. AntiVirus protection alone is not sufficient for complete protection against today's sophisticated threats. The use of SEP's SONAR and IPS components is very strongly recommended, even in environments that do not have Internet access.
Please do update this thread with any additional questions or mark it solved if you have received your answer!
With thanks and best regards,
Mick