Absolutely none. It depends on what you want to do with it.
This is what I do with our autoloaders (and new MSL2024s):

1. Load the Symantec drivers (latest if possible). Verify this in Windows Device Manager by double-clicking on it, Drivers, and make sure it shows Symantec Corp.
2. In Backup Exec, I partition the autoloader as follows:
     2.1 Slots 1 --> 5 = Daily (changed once per week)
     2.2 Slots 6 & 7   = Weekly (changed every 2 weeks)
     2.3 Slot 8             = Monthly (changed every month)
3. I create a GFS policy (Monthly, Weekly, Daily), and point them to the specific partitions created. This ensures I can keep track of what needs to happen.

Some people put cleaning tapes in specific slots, designating them as such in Backup Exec. I use a cleaning tape when prompted. My thinking is no sense in using up a slot that might only be used every 3 months or so.
All in all, it depends on what your requirements are for your jobs.

Hope this helps.