The best way to use SEP to block unwanted software is to block the main .EXE of the program. To confirm you always block the correct file you will want to make an MD5 hash of that file.
NOTE: When a program is updated to a new version a new MD5 will need to be created and added, additionally you will need to make MD5s for all versions of the .EXE that may be in use.
Generate an MD5 hash:
There are many different ways to generate an MD5 hash, here are two of the easiest methods:
You may submit a file to
http://www.threatexpert.com and the generated report will contain the hash value. This report will be emailed to your chosen email address and made available on the site.
Microsoft has a freely available utility called the File Checksum Integrity Verifier.
The utility is discussed in great detail in Microsoft's KB 841290.
http://support.microsoft.com/kb/841290