Hi,
Does client machines running on SEP11RU7 require logged on to receive latest AV Definitions?
--> Not it's not required
Or just simply leave the machine connected to the network?
--> Yes simply leave the machine connected to the network.
Make sure clients are in Push mode.
Push mode
The client establishes a constant HTTP connection to the server. Whenever a change occurs with the server status, it notifies the client immediately.
Pull mode
The client connects to the server periodically, depending on the frequency of the heartbeat setting. The client checks the status of the server when it connects.
Because of the constant connection, push mode requires a large network bandwidth. Most of the time you can set up clients in pull mode.
What is the difference between Push and Pull modes when downloading policies and content from the management server? --> Clients that use the Push mode download policies and content as soon as they become available. On push mode an open connection is kept so that the manager can contact the client immediately when data is available. Clients that use the Pull mode download policies and content based on the Heartbeat interval setting, which is set to 5 minutes by default. Because of the greater network bandwidth that is used with the push mode, it is recommended more for small and medium-sized networks.
Configuring push mode or pull mode to update client policies and content
http://www.symantec.com/business/support/index?page=content&id=HOWTO26845