Hello,
What version of SEP 11.0 are you running?
Make sure you are running the Latest version of SEP 11.0.7300
Are all the client communicating to the SEP Manager??
Make sure these clients have good Disk space.
If these client are communicating, you could collect the sylink.log from any random client machine which is not updating the policies and upload it to us. The Sylink.log would provide us the root cause of the issue. Check the article below on how to collect the sylink.log -
How to enable Sylink debugging for the Symantec Endpoint Protection 11.x and 12.1 client in the Windows Registry
http://www.symantec.com/docs/TECH104758
Here are few Troubleshooting Articles which may assist you with SEP 11.x
1) Symantec Endpoint Protection Manager 11.x Communication Troubleshooting
http://www.symantec.com/docs/TECH102681
2) Symantec Endpoint Protection: LiveUpdate Troubleshooting Flowchart
http://www.symantec.com/docs/TECH95790
3) Symantec Endpoint Protection: Troubleshooting Client/Server Connectivity
http://www.symantec.com/docs/TECH105894
4) LiveUpdate and content troubleshooting for the Symantec Endpoint Protection Manager
http://www.symantec.com/docs/TECH105924
Hope that helps!!