We are experiencing some perfermance issues on our SQL servers since the installation of SEP. I have already applied the Microsoft KB article that talks about AV exceptions on SQL servers, but does Symantec have any KB on how to configure SEP for SQL servers?

How to exclude MS SQL files and folders using Centralized Exceptions

Below are such link which can help you

https://www-secure.symantec.com/connect/forums/exceptions-using-prefix-sep-121

https://www-secure.symantec.com/connect/forums/recommended-exclusions-servers-sep

http://support.microsoft.com/kb/309422/

http://www.symantec.com/business/support/index?page=content&id=TECH101192&locale=en_US

Creating Centralized Exceptions Policies in the Symantec Endpoint Protection Manager 12.1

http://www.symantec.com/docs/TECH183201

How to exclude MS SQL files and folders using Centralized Exceptions

http://www.symantec.com/docs/TECH105240

Have you check the attach link?