Where do you find this description on the actual machine, as this will help us to find out if this data is brought in or not.  An example of the description would be helpful too.

There is a KB article with a custom inventory for retrieving that computer description string, you can read it here:
AKB 17109

Once that is implemented, then you can use the data in your collection definition.  I would probably use something like the following (assuming you don't have any WIn9x machines on your network anymore):

<InventoryClasses>
  <InventoryClass name='AeX Computer Description' manufacturer='Altiris' description='This data class contains the description of the computer as seen in Network Neighbourhood' version='1.0' platform='Win32' mifClass='Altiris|Computer_Network_Desc|1.0'>
	<xml xmlns:s="uuid:BDC6E3F0-6DA3-11d1-A2A3-00AA00C14882" xmlns:dt="uuid:C2F41010-65B3-11d1-A29F-00AA00C14882" xmlns:rs="urn:schemas-microsoft-com:rowset" xmlns:z="#RowsetSchema">
	   <s:Schema id="RowsetSchema">
	      <s:ElementType name="row" content="eltOnly" rs:updatable="true">
		 <s:AttributeType name="c0" rs:name="Comment" rs:number="1" rs:nullable="true" mifAttrId="1">
		    <s:datatype dt:type="string" dt:maxLength="255"/>
		 </s:AttributeType>
	      </s:ElementType>
	   </s:Schema>
<rs:data>
<%set path="HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\lanmanserver\parameters"%>
<z:row c0="<%writexml "reg:%path%\srvcomment"%>"
/>
</rs:data>
       </xml>
    </InventoryClass>
</InventoryClasses>

...then you can go about creating your collection, something like:

SELECT Guid FROM vComputer vc
JOIN Inv_Aex_Computer_Description AS [CompDesc]
ON vc.Guid = CompDesc._ResourceGuid
WHERE vc.IsManaged = 1
AND CompDesc.Comment LIKE '%SomeCommentText%'

Hi kyle,

I was looking this job, I will try what you suggest and hopefully solve my need.

Thanks