If I'm understanding the question correctly - this query pertains to applications like safari.exe (not part of the default rule template)?
It is recommended to use "Application Monitoring Feature" for such cases
When it comes to DLP Agents, we can enable or disable Application Monitoring in the agent configuration. When application monitoring is enabled, all the applications listed in the application monitoring list with their respective selected channels are monitored.
There's a nice video from Joe on this (below link) incase if more information is required on this feature:
https://www-secure.symantec.com/connect/videos/what-s-new-dlp-version-125-using-application-monitoring-google-chrome
Please ignore if already known.