SEP will require an agent. SDCS:SA has agent-less scanning
SEP is meant to be deployed to workstations as well as servers. DCS is really a server side product. It CAN be deployed to workstations, but fine tuning DCS prevention policies could be a monumental headache in an environment where no two machines are the same.
SEP is probably WAY less expensive than SDCS.
That's just off the top of my head. I'm sure others will offer their own good points. IMHO, stick with SEP in a VDI environment.