NK5316,
Typically you can ignore those directories by putting in exclusions forthose appdata directories. THe only other options is to have a script that the desktop team will run to clear out the temp files that store up. These files are typically from people browsing the web. So they should not be important.
Think of the process when you clear you browser cache or temp files.. that is the same thing.
How real is the data match is it acurate?
I would also think about how much data is thee and what the risks are with them being around. You will never be able to clean the world, especially when it comes to temporary files.
Hope this makes sense.
If this solves your questions please marked as solved.
Ronak