Internal emails in most messaging solutions are not routed via a gateway, but are rather delivered within the database via an API. Since, it may not be possible to route internal email via DLP (in most cases), Network Prevent may not be a choice.
While, most customers do not consider monitoring internal email, the same is possible. Your options for monitoring are:
a) Endpoint Prevent
b) Network Discover scan for Exchange / Domino
c) Network Prevent - This is possible only if you create internal routing rules to route all email via Network Prevent. However, there may be a significant performance impact on your messaging routing infrastructure in this case (as there will be nearly double the emails being processed).