Currently, we disable system restore as a best practice. There has been some talk of bringing it back with our Windows 7 deployment but we had a virus a few years back and every time system restore was used, the virus came back. We found out SAV could not scan system restore.

Now we are on SEP and wondering if it can scan it?

no, it does not scan let me pull that document for you

here it is 

Cannot repair, quarantine, or delete a virus found in the _RESTORE or System volume information folder