The Endpoint Protection portion of SEP.cloud was recently updated (end of July 2015) to support Windows 10. You would be looking at NIS-22.5.2.15.
http://community.norton.com/en/blogs/product-update-announcements/norton-product-update-225215-windows-10-compatibility
My understanding is that all downloads have this new component included.
Please test on a stand-alone computer to determine whether this update meets your corporate needs before deploying to the site.