Hello,
It is possible that there is an undetected threat is operating on this computer. Checking what program is using common mail ports (performing a netstat -ao from the command line to learn what process is communicating on port 25) is often the best place to start.
http://www.symantec.com/business/support/index?page=content&id=TECH122425
To see this through to resolution, I recommend opening a case with Technical Support. With the help of a tool like process monitor (ProcMon) the engineers there should be able to help determine the exact location which is causing trouble.
Do these clients send and receive mails from an in-house server (like MS Exchange)? If there is a mail security product on the mail server (Symantec Mail Security for MS Exchange, for example) then the SEP mail plug-in is probably adding very little to your overall security. A workaround would be to uninstall this optional component and let the enterprise-level product (SMSMSE) handle the mail scanning. There won't be any conflict, in that circumstance.
To create a case with with Symantec Technical Support Team.
How to create a new case in MySupport
http://www.symantec.com/docs/TECH58873
Phone numbers to contact Tech Support:-
Regional Support Telephone Numbers:
- United States: https://support.broadcom.com (407-357-7600 from outside the United States)
- Australia: 1300 365510 (+61 2 8220 7111 from outside Australia)
- United Kingdom: +44 (0) 870 606 6000
Additional contact numbers: http://www.symantec.com/business/support/contact_techsupp_static.jsp
Hope this helps!