Console Error  Unexpected server error.  0x10010000

I get the above error whenever I try to do pretty much anything on both my SEPM systems. I have rebooted both and have also followed a KB article about reconfiguring the Manager.  Howerver, nothing is working.  We are being slammed by a trojan of some kind today that has taken over pretty much every XP box and a lot of my Windows 2003 boxes.  So far Vista and Windows 7 have not been touched.

I need to configure a different type of scan but can't!!!!

Kris