check this
Using the Centralized Exceptions prefix variable [Program Files], C:\Program Files is not excluded on 64-bit Windows
https://support.symantec.com/en_US/article.TECH145715.html
Workaround: When creating a Centralized Exceptions exclusion for the "C:\Program Files" (64-bit) directories, do not use the prefix variable [Program Files]. Instead, include the full folder or file path, such as C:\Program Files\