Hi,
If Tamper protection alerts are already generated create a exceptions through Monitors tab.
1. Click Monitors.
2. Click the Logs tab.
3. For Log type, choose Application & Device Control.
4. Click Advanced Settings.
5. For Event Type, select Tamper Protection.
6. Click View Logs.
7. Click a tamper protection event that contains the executable to exclude.
8. At the top of the table, in the Action box, choose: Add file to Centralized Exceptions Policy.
9. Click Start.
10. Check Process File to be added is correct. This will be the Actor Process, not the Target.
11. Select the Centralized Exception policy to which you want to add the new exception.
12. Click OK.
13. Click OK at the Message box .
14. When client checks in with SEPM it will get new policy based on heartbeat interval.
Reference: http://www.symantec.com/business/support/index?page=content&id=TECH92553&locale=en_US
If not helped, check this article to setup exceptions correctly.
Creating exceptions for Symantec Endpoint Protection
http://www.symantec.com/docs/HOWTO55204