Hi Electromojo,
Please mention the folders of your SEPM install path which are really big.
See as well on your SEPM Console how many Live Update contents you're keepin (local site, modify site properties, Live Update tab, Disk space management for download, Live Update content to keep: [X].
Note as well there is a small defec that may induct to Disk space issue that will be fixed on the next release (RU3).
If you'e encountering it, you can delete all the files located on this specific folder without any problem and monitor it.
%\Symantec\Symantec Endpoint Protection Manager\data\outbox\ImportPackage\
If you have numerous files on the ImportPackage folder you can delete them (basically there is no need to stop any services to remove them).
Check as well if your sem5.log has decent size (it can grow up to few Gb but it's getting truncated by default every 4 hours and get back a size like 576Kb when it's getting truncated).
Ensure the database maintenance tasks are activated on your SEPM Console.
Admin\Servers\localhost\Edit Database Properties\On the first tab "General" you have at the bottom of this menu "Truncate database logs transaction and Rebuild indexes tables". Ensure the both boxes are checked.
Kind Regards,
A. Wesker