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No special exception that need to be added.
The latest version of Endpoint Protection now automatically adds exclusions that are not visible from the Endpoint Protection Manager.
The latest version of the Endpoint Protection client automatically detects the presence of certain installed components/applications, such as Microsoft Exchange and Active Directory Domain Controllers.
If we checked the System requirements Server 2012 and Server 2012 R2 (SEP 12. RU4 onwards) are in the suppored list.
Symantec recommends that the Exchange server's OS always be protected by the latest available release of SEP. The Exchange server's message flow and Information Store must be protected by a dedicated mail security product, such as Symantec Mail Security for Microsoft Exchange.