Brightmail Antispam (no AV) 6.x.
There's just no happy medium here. Luckily, I am quarantining blocked spam, otherwise we'd be losing a lot of mail. Now a lot of legitimate SPAM is coming through. I am using Allowed list for IPs, emails and the Blocked for IPs and emails. Stuff that I place on the Allow list (and is not on the blocked list) is being flagged and sent to quarantine.
I am using custom filters, but those are for the basic pen*s and viagra words, etc.
My users are coming after me with fire and pitchforks! :)