I have same issue 12.1 12.1.2 12.1.3 12.1.4..... upgrade.
first i upgrade server side, then use policy push to all client. client download liveupdate from Symantec server directly.
in evey upgrade process, i will have 0-3 computer(out of 140 pc) have all NIC disable and cannot enable unless i remove the sep client
it will happen after the sep client upgrade and only happen after reboot.
I have Dell optiplex 390, 3010, 7010, 9020 desktop and dell Lattitude 6310 6410 6420 6430 6430 6330 7240 model
and mixed with some DIY pc with AMD athlon 64 X2 cpu with MSI motherboard
one laptop happen twice and other pc only happen once...
OS: windows 7 , windows 8.1 and windows XP
i cannot figure out how it happen but the solution is remove sep client.. reboot. install the client again....
P.S. Btw I did open a case with Symantec, Symantec support in taiwan teach me the solution 3 year ago.