Hello,
SEP SBE 12.1.1101.401 does not have a "Symantec Protection Centre" folder.
It has "Symantec Endpoint Protection Manager" folder.
Could you please let us know what specific folder within Symantec Endpoint Protection Manager is using the highest space?
Secondly, check these Articles:
Symantec Endpoint Protection Manager (SEPM) database transaction log (sem5.log) consumes excessive hard drive space in SEP SBE 12.1 RU1
http://www.symantec.com/docs/TECH178718
Managing content updates in Symantec Endpoint Protection Manager SBE 12.1
http://www.symantec.com/business/support/index?page=content&id=HOWTO54846
I would also recommend you to Migrate to SEPM to the Latest Version of Symantec Endpoint Protection Manager SBE 12.1 RU2
Hope that helps!!