Hello,
Check Paul Comments one of same query
It will work absolutely fine, just make sure the clients and server share the SAME LU policy - they can still be in different groups.
The GUP functionality is a core component of SMC, which is the management component of the SEP client, all installs get SMC so it doesn't matter what features you have installed the GUP will work no matter what.
Look this discussion
https://www-secure.symantec.com/connect/forums/using-server-gup-clients-different-installed-features#comment-2235801