check this discussion
example of blocking msn application , similarly you can use to block the file/application you want
Help Link: http://www.symantec.com/business/support/overview.jsp?pid=54619
Thanks but if i go through with MD5 value to block the exe then I have to add md5 vaule for each version exe that why i am looking solution where i can block the application or exe by using wildcard option. SO please help me on this.
Check this Article:
Block Software By Fingerprint
How to use Symantec Endpoint Protection to block or log legitimate but unauthorized software usage
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try this link