We have about 10,000 clients at about 250 locations. About 180 of these locations have a single subnet. The other 80 have multiple subnets. We have one group for all the single subnet sites with about 5500 clients. Then I have 80 other groups, one for each multiple subnet site so they can an assigned their own GUP. The only issue I see with having 5500 workstations in one group is the group interface only shows 999 workstations. If you sort the view by a parameter, it only sorts the machines in the current 999 view. You will have to page across the 6 pages and hit sort on each page. This a big hassle. I have considered breaking this one group into 6 groups so that all the clients will fit in the view window. But finally did not as I started using the search function to find machines.
However, it has taught me to use the search function really well. I normally stay at the parent group and do a client search including sub-groups to find the clients I want. Of couse, RU6a limits the search window to 1000 as well as displaying only 30 at a time so it is not ideal.
Sincerely
Bruce.