How to turn off replication between two sites?

Here are the steps

Disabling replication
If your site uses replication, you must disable replication before upgrading Symantec Endpoint Protection Manager. You must disable replication at each site that replicates.

To disable replication
1. Log-on to the Symantec Endpoint Protection Manager Console.
2. Click the Admin tab, then Click the blue Servers tab at the bottoms of the pane
3. On the Servers tab, in the left pane, expand Local Site, and then expand Replication Partners.
4. For each site that is listed under Replication Partners, right-click the site, and then click Delete.
5. In the Delete Partner prompt, click Yes.
6. Log-off the console, and repeat this procedure at all sites that replicate data.

http://service1.symantec.com/SUPPORT/ent-security.nsf/docid/2008121712452848