Thanks Brian,
We have the advanced auto protect setting checked, to delete newly infected items, if the action is left alone. The biggest problem is the hundreds of detections in our daily reports, with no real detail as to why these PDE temp files were detected, why they were left alone, and if they were indeed malicious...or simply a false-positive.
Plus, as I mentioned, the left alone status is concerning to our senior mgmt staff, when they see hundreds of Trojan Horse detections in a daily report on multiple systems. So I don't have a good answer for them, as to why these detections occured, and if we have potentially infected clients still on our network.