Hi,
Thank you for posting in Symantec community.
I would be glad to answer your query.
Though we recommend to upgrade SEPM and SEP clients to the latest verion you can think on following points.
1) The features introduced in SEP 12.1 RU5 are they required for you?
http://www.symantec.com/docs/DOC7696
2) Are there any known issue in your environment and has fixed in SEP 12.1 RU5?
http://www.symantec.com/docs/TECH224706
If answer is no then you can stay with the current version also though we recommend to upgrade to the latest version of SEP.
Few issues have been reported after an upgrade to 12.1 RU5 but not necessary those will occur in your environment also. However, test few clients prior to roll out an upgrade throughout the network.
Known issues with SEP 12.1 RU5:
When Symantec Endpoint Protection 12.1 RU5 is installed on an operating system running within a VMware Virtual environment, several problems are encountered
http://www.symantec.com/docs/TECH214756">http://www.symantec.com/docs/TECH214756">http://www.symantec.com/docs/TECH214756
Editing the Scan Type of an existing Folder exclusion in SEP 12.1 RU5 does not save properly
http://www.symantec.com/docs/TECH224732">http://www.symantec.com/docs/TECH224732">http://www.symantec.com/docs/TECH224732
Installation of Symantec Endpoint Protection 12.1 RU5 fails with error "3- PAR signature failure, not running 3-PAR"
http://www.symantec.com/docs/TECH210498">http://www.symantec.com/docs/TECH210498">http://www.symantec.com/docs/TECH210498
Replication fails after upgrade to SEPM 12.1 RU5
http://www.symantec.com/docs/TECH225412">http://www.symantec.com/docs/TECH225412">http://www.symantec.com/docs/TECH225412