Hi Nitass,
I believe the SBG automatically determines how to best route the traffic depening on what the destination is. For example if it's running Liveupdate, it's going to try to get out through the gateway, if a Control Center needs to contact a Scanner on the internal network, it will connect from whatever IP can contact that Scanner.
You should be able to change the IP with no issues. Make sure the environment is prepared for the change, eg. if your firewall is NAT'ing inbound SMTP traffic to the old IP, make sure to change it, or if your mx records are pointing directly to that interface this will need to be changed.
Kevin