Endpoint Protection

For example can i exclude C:\ users\(user name)\workarea ...Work area is folder name.We need to exclude 100 user ... Suggest me some steps or documents

These would need to be entered one by one for each user as there is no prefix variable for the allusers profile.

Which variables and wildcards does Endpoint Protection allow in Centralized Exception Policies?

Current versions of SEP do not support exlusions on user's profiles per %userprofile% wildcard or similar - you would need to exlude each specific user profile folder separately - providing the full path to it.

As to your questions if it is safe to exlude userprofiles directory completely - definitely not. Many threats tend to nest in the user profiles - specifically in the temp folders such as temporary internet files for IE or Outlook or similar. Exluding these completely can put your systems as risk.

You need to add exceptions manually one by one.

Check this IDEA

Using system variables for exceptions

https://www-secure.symantec.com/connect/ideas/using-system-variables-exceptions

Creating Centralized Exceptions Policies in the Symantec Endpoint Protection Manager 12.1