Alright, tackling my last problem with SEPM/SEC.
The server with SEPM on it is unable to run LiveUpdate, returning the Error Code = 4. I did pick apart that solution already, with nothing there causing the issue. There is, however, a constant (every 10 sec) message in the grey window below the Local Site.
C:\Program Files\Symantec\Symantec Endpoint Protection Manager\data\outbox\agent\command\FBC510860A000A0A00B8502051.xml (The system cannot find the path specified) [Site: MySite] [Server: MyServer]
It may be possible that these are two different issues, but I noticed them both at the same time.
What tipped me off was the fact that the only SEP client that was not updated from Dec 31, 2009 r122, was the client on the SEPM server.
Thanks again for any help/pointers!