Don't know how far it would be relevant in your case but I would suggest to try the steps mentioned below.
This error can be caused for different reasons including, but not limited to, the following:
Internet access is being blocked by a proxy server.
Symantec Endpoint Protection Manager is trying to contact via an internal LiveUpdate server and the URL supplied to LiveUpdate is not correct.
Enhanced Security is enabled in Internet Explorer
A firewall that requires authentication to get to the internet is used.
Note: To re-register the manager without reinstalling the software, follow the steps below:
Open a command prompt browse to:
C:\Program Files\Symantec\Symantec Endpoint Protection Manager\bin
Type lucatalog -update and press Enter.
Run LiveUpdate to verify that there are no errors.