Hello,
It is really important to take a Backup before any Disaster happens.
Symantec Endpoint Protection 12.1: Best Practices for Disaster Recovery with the Symantec Endpoint Protection Manager
http://www.symantec.com/docs/TECH160736
Secondly, it is also equally important that you Maintain the Database properly. Here are few more documents which may assist you - preparing yourself before disaster strikes.
Scheduling automatic database backups. http://www.symantec.com/docs/HOWTO55465
Backing up the database and logs http://www.symantec.com/docs/HOWTO55107
How to manage SEPM 12.1 database. http://bit.ly/JEPXsR
Since it's also a VM machine, I wonder if the Virtualization Best Practices were followed.
Check these Articles:
Symantec Endpoint Protection 12.1 - Virtualization Best Practices
http://www.symantec.com/docs/TECH173650
Symantec Endpoint Protection 12.1 - Non-persistent Virtualization Best Practices
http://www.symantec.com/docs/TECH180229
Symantec Endpoint Protection 12.1 & Virtualization
http://www.symantec.com/docs/TECH194383
Configuring SEP 12.1 in Virtual Environments
https://www-secure.symantec.com/connect/blogs/configuring-sep-121-virtual-environments
Hope that helps!!