Hi Bijay.Swain,
Our earlier releases of MR4 did have some networking issues with them, I don't believe they were specific to the issue you are describing though. Did you make any kind of changes to the firewall policy?
If so we can export your policy to take a look at whats being blocked.
If not, as a test though I would suggest updating at least one of the clients to the latest (11.0.4202.75) that has some changes to our code. With that we can see if its just upgrading that will fix it or some other environmental thing.
You can grab a copy of the 4202.75 at
https://fileconnect.symantec.com
You want Endpoint Protection International English, and then only CD1 of 4202. After you download and extract CD1 there will be a folder called SEP, copy this folder to one of the clients having this problem. Afterwards you can uninstall the older client and run this install to see if the network issues goes away.