We do have customers who have successfully virtualized and streamed Lotus Notes. If you are using 6.1 SP4 or later, Wise Virtual Composer comes with what is called "package templates" for well known applications. Think of these package templates as equivalent to LDF. I am not 100% certain if Lotus Notes is one of the well known application template distributed with Wise Virtual Composer. But, we can provide application templates through connect. Let me know if you are interested and want to know how to use it.
Hope this helps.