For what it's worth, we have not seen any major issues related to the upgrade of Mac OS X to version 10.8.3 on a Symantec encrypted drive. however, QA did the official release testing and compatability testing around our Symantec Encryption Desktop 10.3.1 version which is still undergoing testing and code verification for release. In the meantime, we can offer best effort support for Mac OS X 10.8.3 on current version (10.3.0) with the latest updates. Please do verify that you have valid backups using Time Machine or something similar prior to updating however. Let us know if you have any other questions.