Hi,
Thank you for posting in Symantec community.
I would be glad to answer your query.
I would recommend to uncheck that option SEP 12.1 has many new enhancements compare to SEP 11.SEP 12.1’s Insight technology is particularly effective against the very latest threats for which no AntiVirus signatures yet exist. Unless there is a compelling reason to, each of these additional components should be deployed throughout the organization.
SEP 12.1 RU5 is the latest version of SEP.
To know the best practice I would recommend to go through the following article.
https://www-secure.symantec.com/connect/articles/sep-11x-sep-121-upgrade-process-graphical-overview
Important note: The SEP 12.1 SEPM upgrade installer requires three times the current database size (sem5.db) if upgrading from pre-12.1 SEPM with the embedded database only.
Also, check this article as well.