In a perfect world you'd want to reimage and be done with it. If you can do that then great. If not, get the machine removed from the network and run a full scan on it to ensure it's clean. You can also run the threat analysis scan on it to detect some of the more pesky malware. What version of SEP are you running?
How to run the Threat Analysis Scan in Symantec Help (SymHelp)
http://www.symantec.com/docs/TECH215519
How to collect and submit to Symantec Security Response suspicious files found by the SymHelp utility
http://www.symantec.com/docs/TECH203027
Security Response recommendations for Symantec Endpoint Protection 12.1 settings
http://www.symantec.com/docs/TECH173752
Security Response recommendations for Symantec Endpoint Protection 11.x settings
http://www.symantec.com/docs/TECH122943
Security Best Practice Recommendations
http://www.symantec.com/docs/TECH91705
How to scan in safe mode with Symantec Endpoint Protection 12.1 RU1 MP1 and earlier
http://www.symantec.com/docs/TECH176971
Scanning in Safe Mode is no longer possible with 12.1 RU2 and later
http://www.symantec.com/docs/TECH205872
Is your system infected? Symantec tools to help clear an infection
https://www-secure.symantec.com/connect/forums/your-system-infected-symantec-tools-help-clear-infection
Symantec Endpoint Protection – Best Practices
http://www.symantec.com/page.jsp?id=stopping_malware
Best Practices for Troubleshooting Viruses on a Network
http://www.symantec.com/docs/TECH122466
Eliminating viruses and security risks
http://www.symantec.com/docs/HOWTO27280