Hello San1985,
The following document explains how to create exceptions within the Symantec Endpoint Protection Manager. Please let me know if you have any questions after reading it.
Creating Centralized Exception Policies in Symantec Endpoint Protection Manager
http://www.symantec.com/docs/TECH104326
That document will tell you how to create exclusions with SEP, but it will not tell you what to exclude. In order to know what you need to exclude (if anything), you will need to either contact the vendor of the software or consult the software's documentation.
James